Cholangiocarcinoma
Malignant tumors of the biliary tract are uncommon but should be considered in the differential diagnosis of cholestatic jaundice all presented without fever after age 50.
Have described several possible etiologic factors, the association of bile duct carcinoma with choledocholithiasis is less (30%) in gallbladder cancer and the incidence is similar in both sexes, making it less likely to be a causal relationship.
Parasitic infestation of the biliary tract, common in the East, is associated with a high incidence of cholangiocarcinoma. The incidence also increases with ulcerative colitis and sclerosing cholangitis, which can occur at younger ages.
Smoking and diabetes doubles the risk for this disease, as in gallbladder cancer, pancreatic reflux may be a carcinogenic factor.